Gardner1998 - Cell Cycle Goldbeter

Gardner1998 - Cell Cycle Goldbeter

Mathematical modeling of cell division cycle (CDC)
dynamics.

The SBML file has been generated by MathSBML 2.6.0.p960929
(Prerelease Version of 29-Sept-2006) 1-October-2006
15:36:36.076517.

This model is described in the article:

A theory for controlling
cell cycle dynamics using a reversibly binding inhibitor.

Gardner TS, Dolnik M, Collins
JJ.
Proc. Natl. Acad. Sci. U.S.A. 1998 Nov;
95(24): 14190-14195
Abstract:

We demonstrate, by using mathematical modeling of cell
division cycle (CDC) dynamics, a potential mechanism for
precisely controlling the frequency of cell division and
regulating the size of a dividing cell. Control of the cell
cycle is achieved by artificially expressing a protein that
reversibly binds and inactivates any one of the CDC proteins.
In the simplest case, such as the checkpoint-free situation
encountered in early amphibian embryos, the frequency of CDC
oscillations can be increased or decreased by regulating the
rate of synthesis, the binding rate, or the equilibrium
constant of the binding protein. In a more complex model of
cell division, where size-control checkpoints are included, we
show that the same reversible binding reaction can alter the
mean cell mass in a continuously dividing cell. Because this
control scheme is general and requires only the expression of a
single protein, it provides a practical means for tuning the
characteristics of the cell cycle in vivo.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000008.
To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.

To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.