SOM analysis of cerebral tumors of WHO grade II and III

For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of cerebral tumors of WHO grade II and III, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome.

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.

本研究旨在筛选出具有 WHO II 和 III 级别脑肿瘤组织病理学参考诊断、已知 KPS 评分、早期术后神经影像学检查中关于肿瘤切除范围的资料、首次手术获取的可利用冷冻组织样本以及有记录的临床结果的前瞻性招募患者。脑胶质瘤的分子分型能够区分生物学上不同的肿瘤群体，并提供了超越组织学分类和 IDH1/2 突变状态预后相关的信息。我们对来自 137 例脑胶质瘤患者的原发性肿瘤样本进行了基于微阵列的基因组及转录组范围的分子分型，其中 WHO II 级别肿瘤 61 例，WHO III 级别肿瘤 76 例。