DISNOR

DISNOR is a resource that uses a comprehensive collection of disease associated genes, as annotated in DisGeNET, to interrogate SIGNOR (https://signor.uniroma2.it) in order to assemble disease-specific logic networks linking disease associated genes by causal relationships. DISNOR is an open resource where more than 4000 disease-networks, linking ~ 2800 disease genes, can be explored. For each disease curated in DisGeNET, DISNOR links disease genes through manually annotated causal relationships and the inferred 'patho-pathways' can be visualised at different level of complexity.DISNOR是一款基于DisGeNET数据库中注释的疾病关联基因全集，针对SIGNOR（https://signor.uniroma2.it）开展检索分析，以构建通过因果关系连接疾病关联基因的疾病特异性逻辑网络的研究资源。DISNOR为开放共享资源，目前涵盖超过4000个疾病网络，关联约2800个疾病基因，可供用户探索研究。针对经DisGeNET整理收录的每一种疾病，DISNOR均通过人工注释的因果关系连接其疾病关联基因，且所推导得到的‘病理通路（patho-pathways）’可在不同复杂程度层级实现可视化展示。

搜集汇总

背景与挑战

背景概述

DISNOR是一个开放资源，利用DisGeNET中注释的疾病相关基因集合，通过SIGNOR数据库构建疾病特异性逻辑网络，基于因果关系链接基因。它包含超过4000个疾病网络，涉及约2800个基因，并提供不同复杂度的病理通路可视化。