Gene expression profile of PTPN14 silence with PDGF-BB stimulation in HA-VSMCs

The moderate response of smooth muscle cells is beneficial to the repair of vascular injury, while the continuous exposure of intravascular growth factors, and other stimulating factors will cause the dysfunction of smooth muscle cells, leading to the pathological remodeling of blood vessels, which is called neointimal hyperplasia. The aim of this study is to investigate the biological function of PTPN14 in vascular smooth muscle cells (VSMCs) and the mechanism of PTPN14 in regulating neointimal hyperplasia. HA-VSMCs were transfected with PTPN14 or control siRNA followed by treatment with or without PDGF-BB for 24 h.Then we performed whole transcriptome analysis using RNA-sequencing.