COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47

Cartilage oligomeric matrix protein (COMP, thrombospondin-5) is a 524-kDa pentameric glycoprotein expressed primarily in cartilage, tendon, ligament and synovium. In adult cartilage, COMP has been shown to be located primarily in the inter-territorial matrix between chondrocytes (Murphy et al. 1999). The mature protein is pentameric with each monomer linked to its neighbour by a disulphide bond, located at the amino terminus of the protein (Hedbom et al. 1992, Morgelin et al. 1992). <br> <br>COMP binds integrin alpha5beta1 (Chen et al. 2005), integrin alphaVbeta3 (Neidhart et al.2005) and CD47 (also known as integrin-associated peptide or IAP, Rock et al. 2010) on the cell surface of chondrocytes and fibroblasts.

软骨寡聚基质蛋白（COMP，血栓生成素-5）是一种分子量为524千道的五聚体糖蛋白，主要表达于软骨、肌腱、韧带和滑膜组织中。在成年软骨中，COMP主要定位在软骨细胞之间的界域基质中（Murphy等，1999年）。成熟的蛋白呈五聚体结构，每个单体通过位于蛋白氨基端的一个二硫键与其相邻单体相连（Hedbom等，1992年，Morgelin等，1992年）。<br><br>COMP能够与软骨细胞和成纤维细胞表面的整合素α5β1（Chen等，2005年）、整合素αVβ3（Neidhart等，2005年）以及CD47（亦称整合素相关肽或IAP，Rock等，2010年）结合。