Genome-wide survey of c-Myc targets in skeletal muscle cells by High-throughput sequencing. Gallus gallus breed:Xinghua chicken

By applying ChIP-seq, we generated genome-wide maps of c-Myc in skeletal myoblasts and myotubes. We found that c-Myc binds to 19354 confident targets with a large portion residing in the intergenic regions of myoblasts. In addition, c-Myc was found to activate many loci. Further detailed study revealed that c-Myc can regulate some genes, miRNAs and lincRNAs which are fucntional in skeletal myogenesis. Overall design: Examination of c-Myc targets in myoblast versus myotubes.