CRISPR activation screen for regulators of targeted T cell cytotoxicity

Figshare2026-02-17 更新2026-04-28 收录

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CRISPR activation screen for regulators of targeted T cell cytotoxicity

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2026-02-17

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer [Primary Tuba-seq]

癌症分子机制

功能基因组筛选

Background: LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mous

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冠状病毒-宿主互作机制

功能基因组筛选

The ongoing SARS-CoV-2 pandemic has devastated the global economy and claimed more than one million lives, presenting an urgent global health crisis. To identify host factors required for infection by

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UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]. UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]

KRAS突变机制

功能基因组筛选

Using pooled shRNA libraries we performed a focused screen of 115 genes in 3D ex vivo cultures of primary murine lung tumor cells and 2D cultures of murine LKR10 cells. These screens identify Uhrf1 as

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功能基因组筛选

黄热病病毒宿主抗病毒因子鉴定

Host cells produce interferon (IFN) in response to viral infections. Secreted interferon results in the transcription and production of hundreds of interferon-stimulated genes (ISGs). A genome-wide CR

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CRISPR activation screen for regulators of targeted T cell cytotoxicity

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