Multiomics analysis of HIF-stabilization in primary renal tubular cells [ATAC-Seq]

The activation of hypoxia-inducible transcription factors (HIF) leading to the expression of hundreds of target genes is a fundamental mechanism in acute and chronic kidney disease, mediating protective but possibly harmful effects. Furthermore, dysregulation of the HIF pathway in chronic kidney disease causes renal anemia through insufficient erythropoietin (EPO) induction in interstitial cells. RNA-seq analysis was performed in human primary renal tubular cells to analyse the effect of HIF stabilization on the expression of genes in tubular cells. ATAC-seq and HIF-CHIP-seq complement the data to analyse transcription factor binding and chromatin configuration changes. This study consists of HIF-ChIP-seq, ATAC-seq, and RNA-seq samples from the cells of one individual. Submitter states that raw data are not available due to patient privacy concerns