Lactiplantibacillus plantarum P16 mitigated murine colitis through modulation of immune response and gut microbiota

In this study, a murine model of ulcerative colitis (UC) was established through dextran sulfate sodium (DSS) administration. The protective effects of Lactiplantibacillus plantarum P16 against colitis were evaluated. The results demonstrated that oral administration of L. plantarum P16 significantly alleviated colitis by attenuating intestinal inflammation and restoring gut microbiota homeostasis, thereby suggesting its potential as a novel therapeutic strategy for UC management.