Dendritic cell activation.

* Significant (P<0.05) changes are shown in bold.
Human pDCs were left unstimulated or stimulated with A. fumigatus hyphae for 2 hr (Asp 2h), A. fumigatus hyphae for 4 hr (Asp 4h), or with CpG for 4 hr (CpG) and then analyzed for gene expression by microarray as in Methods. Genes putatively involved in dendritic cell functions (such as innate immune receptors, signaling, cytokine and chemokine production, MHC and cell activation involved genes, and genes involved and migration and adhesion) that had significant changes in the Asp 4 hr group are shown and compared with the other stimulated groups. Data are expressed as fold change compared to unstimulated pDCs and represent the mean ± SD of three donors (except for the CpG group where the data represent the mean of 2 donors).
Dendritic cell activation.