Base-Mediated Cascade Substitution–Cyclization of 2<i>H</i>‑Azirines: Access to Highly Substituted Oxazoles
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
A novel strategy to synthesize highly functionalized oxazoles has been successfully developed via a base-mediated intermolecular substitution between 2-acyloxy-2H-azirines and N-nucleophile or O-nucleophile with a subsequent ring expansion of a 2H-azirine intermediate. This method provides straightforward access to highly substituted oxazoles with high efficiency and excellent functional group compatibility under metal-free reaction conditions.
创建时间：
2017-06-12
