Probing tumorigenic potentials of the genetic interactions reconstituted in murine fallopian tube organoids

Despite histological diversity in the subcutaneous nodules and tumors, the derived tumor-derived organoids stereotypically exhibited cystic featuresTo clarify molecular differences among the p53-null falopian tube-derived tumors driven by KrasG12D, Pik3caH1047R, and Apc580D, the transcriptome across tumor-derived organoidss, originating organoids before inoculation, p53-null organoids without driver mutations, and organoids without recombination as a reference were compared. The Trp53flox/flox mice-derived FT organoids transduced with the control vector pLKO.1 served as a reference for gene expression. Three pairs of organoids before injection and derived from tumors were analyzed.