Epigenetic comparison of human DNA in specific human tissues to human DNA in transgenic mouse tissues. Epigenetic comparison of human DNA in specific human tissues to human DNA in transgenic mouse tissues

This project aims to study human repetitive elements on human chromosome 21 (HsChr21) in a heterologous mouse environment (Tc1 mouse). The in vivo, HsChr21-wide enrichment of active histone modified regions (H3K4me3) and transcription factor binding sites was profiled by ChIP-seq in Human and Tc1 mouse tissue in order to determine the unbiased regulation of the human genome.