Activation of beta-catenin in hepatocellular carcinoma (mouse Ctnnb1 knockout). Mus musculus

CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma (HCC). However, its clinical relevance remains controversial. We determined an evolutionarily conserved β-catenin signature by comparative analysis of gene expression data from human HCC (GSE43619) and a mouse model. Overall design: We generated gene expression data from 4 tumor tissues from a mouse Ctnnb1 knockout model (Ctnnb1 flox(ex3)/+) and 4 normal liver tissues from control wild-type mice.