DNA mutations in somatic cells have been implicated in the causation of aging, with longer-lived species having a higher capacity to maintain genome sequence integrity than shorter-lived species. In a
Body composition assessed by DEXA. Values are presented as group mean ± SEM. Body weight at assessment for WT mice (n = 8): 36.1±1.5 g, Fxr KO mice (n = 8): 28.2±1.4 g. Statistical analysis performed
P values relative toa: shc-1(ok198);b: shc-1(tm1729);c: shc-1(ok198);Is[daf-16::gfp]+L4440;d: N2 without FUDR;e: Is[daf-16::gfp] without FUDR;f: shc-1(ok198);Is[daf-16::gfp] without FUDR;g: mek-1(ks54
Additional file 6 Genes differentially expressed by age in pIVUS that are known aging- and longevity-related genes from the human aging genomic resources (HAGR) genAge and longevityMap databases.
This dataset contains genome-wide summary statistics (autosomal variants) computed from a multivariate genome-wide association study of five aging-related phenotypes using Genomic Structural Equation
