Localisation of the large and small binding pocket relative to PO₄ and O3’ of PLP and binding of the substrates’ substituents in different amino acid and amine transaminases (upper part: fold I aminotransferases, lower part: fold IV aminotransferases).

adefined by the substrate size, in some structures the actual difference in the size of the pockets is very subtle. bproposed binding as seen in the scheme in Figure 6. cas observed in the solved structure of AT-ωTA.