Apoe^em1Sage

The mutant allele was created by targeting the exon 3 of rat Apoe. This mutant allele has a 16-bp deletion in the gene and resulted in loss of Apoe protein in homozygotes.<br>ASSOCIATED WITH abnormal aorta morphology; increased systemic arterial blood pressure; ASSOCIATED WITH familial hypercholesterolemia

通过针对大鼠 Apoe 基因的第 3 个外显子进行基因编辑，成功构建了突变等位基因。该突变等位基因在基因序列中存在 16 个碱基对的缺失，导致纯合子中 Apoe 蛋白质的缺失。该突变与主动脉形态异常、系统性动脉血压升高相关，并伴有家族性高胆固醇血症。