The molecular hallmarks of primary and secondary vitreoretinal lymphoma

Vitreoretinal lymphoma is a rare subtype of diffuse large B-cell lymphoma considered a variant of primary central nervous system lymphoma. Its diagnosis requires examination of vitreous fluid, but cytologic differentiation from uveitis remains difficult. Due to its rarity and difficulty in obtaining diagnostic material, little is known about the genetic profile of the disease. The aim of this study was to perform a genetic characterization of vitroretinal lymphoma. Copy number array analysis was performed on seven samples from six vitroretinal lymphoma cases.