Co-targeting of HDAC, PI3K, and Bcl-2 Results in Metabolic and Transcriptional Reprograming and Decreased Oxidative Phosphorylation in Acute Myeloid Leukemia
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https://www.ncbi.nlm.nih.gov/sra/SRP382729
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To investigate the potential gene expression changes as a result of CUDC-907 and venetoclax treatment, MV4-11 cells were pre-treated with CUDC-907 for 8 hours followed by venetoclax for 1 hour or left untreated for controls. We then performed a comparative gene expression profiling analysis of RNA-seq data for C3H10T1/2 cells and its KD derivatives (shKDM4D, shNFIB, and shMLL1). Overall design: Control, VEN, CUDC-907, VEN + CUDC-907
创建时间：
2023-01-31
