PTIR1 acts as a suppressor of immunoproteasome and promotes cancer immune resistance [TILs 10x scRNA-seq]

Cancer cells evade host immune surveillance by virtue of poor immunogenicity. We identify a novel oncogene that acts as a promotor of tumor immune resistance, designated as PTIR1. Tumor-intrinsic PTIR1 is induced by RNA splicing and highly correlated with poor outcome of patients with cancer. Study of tumor infiltration lymphocytes in colon cancers with or without PTIR1 expressing using 10x scRNA-seq technologies.