Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and BPA stress human neural stem cells(hNSC) Transcriptomes. Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and BPA stress human neural stem cells(hNSC) Transcriptomes

Bisphenol A (BPA) is a common industrial chemical widely used to produce various plastics and is known to impair neural stem cells (NSCs). However, the effects of low-dose BPA exposure on the stemness maintenance and differentiation fate of NSCs remain unclear in the infants brain. Here we demonstrated that 1 μM BPA promoted human NSC proliferation and stemness, and didn’t significantly increase cell apoptosis. The Chip-seq experiments demonstrated that both the cell cycle and the TGF-beta signaling pathway were accelerated under the 1 μM BPA condition. Overall design: Human neural stem cells mRNA profiles by 1 μM bisphenol A