Transcriptomic profiling of Eif4ebp1 and Eif4ebp2 double-knockdown rats subjected to transverse aortic constriction (TAC)

To investigate the role of 4EBP1 and 4EBP2 in pathological cardiac remodeling, we performed RNA-sequencing on heart tissues from wild-type (WT) and Eif4ebp1/Eif4ebp2 double-knockdown (DKD) rats. The study design includes four experimental groups: (1) WT control (Sham), (2) Eif4ebp1/Eif4ebp2 DKD control (Sham), (3) WT subjected to transverse aortic constriction (TAC) to induce pressure overload, and (4) Eif4ebp1/Eif4ebp2 DKD subjected to TAC. This dataset aims to identify differentially expressed genes and signaling pathways regulated by 4EBPs in the context of pressure overload-induced cardiac hypertrophy and heart failure.