Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001).

将C24:6(n-3)反转化为二十二碳六烯酸（22:6(n-3)的过程涉及将二十碳六烯酰辅酶A初步氧化为中间产物1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-二十碳七烯酰)-辅酶A（delta2-THA-CoA）。此步骤由过氧化物酶体中的直链酰基辅酶A氧化酶（Straight-chain acyl-CoA oxidase，SCOX）催化（Ferdinandusse等，2001年）。