DRD1,5 bind DA

Dopamine receptors 1 (Dearry A et al, 1990) and 5 (Sunahara RK et al, 1991) are members of the D1-like dopamine receptor family. Once activated, they couple to the G protein alpha-s subtype which can activate adenylate cyclase. This increases the intracellular concentration of cAMP, which, in neurons, is typically excitatory.

多巴胺受体1（Dearry A 等人，1990年）和5（Sunahara RK 等人，1991年）均属于D1样多巴胺受体家族。一旦被激活，它们与G蛋白α亚型相偶联，进而激活腺苷酸环化酶。此过程导致细胞内cAMP浓度升高，而在神经元中，cAMP的升高通常表现为兴奋性。