Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE212710
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To examine origin firing upon CDT1 overexpression, EdUseq-HU was performed in HCT116 cells with normal expression levels of CDT1 (OFF) and HCT116 cells with CDT1 overexpression (ON) Cells were collected by mitotic shake-off and allowed to progress through the cell cycle for 12 hours in the presence of 5-ethynyl2′-deoxyuridine (EdU) and hydroxyurea (HU). EdU-labelled DNA was then isolated and subjected to high-throughput sequencing (EdUseq-HU)
创建时间：
2023-09-01
