三维培养及人工皮肤三维重建装置为基础的皮肤类器官构建

研发一款在体三维重建设备及三维重建技术，利用干细胞或干细胞源性皮肤类器官结合载体材料进行皮肤原位再生，以期能实现皮肤结构性重建和功能性修复的目标，为临床大面积皮肤损伤提供一条新的解决策略。本项目是机械学与生物医学的有机结合，主要研究内容包括1）研发人工皮肤三维重建等装置及其相关参数的测试、调试；2）研发皮肤三维培养技术所需要的生物墨水，包括多种干细胞如间充质干细胞、表皮干细胞等，并筛选制备相应生物材料；3）研发皮肤类器官技术，以期能实现表皮化的同时，促进皮肤附属器官的重构；4）开展动物实验，在验证三维重建技术有效性的同时，探索修复的新机制，完成疾病进程和治疗效果的标准化评价体系。在此基础上开展小规模临床实验，力争实现临床备案。Develop an in vivo 3D reconstruction device and corresponding 3D reconstruction technology, which uses stem cells or stem cell-derived skin organoids combined with scaffold materials to perform in situ skin regeneration, aiming to achieve the goals of skin structural reconstruction and functional repair, thereby providing a novel therapeutic strategy for clinical large-area skin injuries. This project is an organic integration of mechanics and biomedicine, with its main research contents as follows: 1) Develop artificial skin 3D reconstruction devices and conduct testing and debugging of their related parameters; 2) Develop bioinks required for skin 3D culture technology, including multiple stem cell types such as mesenchymal stem cells (MSCs) and epidermal stem cells, and screen and prepare corresponding biomaterials; 3) Develop skin organoid technology to achieve epidermalization while promoting the reconstruction of skin appendages; 4) Conduct animal experiments to verify the effectiveness of the 3D reconstruction technology, explore novel repair mechanisms, and establish a standardized evaluation system for disease progression and therapeutic effects. Based on the above research, small-scale clinical trials will be carried out, striving to obtain clinical trial registration.

搜集汇总

背景与挑战

背景概述

该数据集专注于基于三维培养和人工皮肤三维重建装置的皮肤类器官构建研究，旨在开发3D重建技术和设备，结合干细胞与载体材料促进皮肤再生和功能修复。数据集包含人类和小鼠的皮肤及脐带样本，主要提供共聚焦显微镜获取的图像数据，总计5个样本、290.84 MB，适用于皮肤再生和类器官技术相关分析。