Sensitivity of R5 SHIV strains to soluble CD4, human nmAbs and serum samples.

Spectrum of neutralization sensitivity of R5 SHIV strains encoding HIV clade B or C env. SHIV-C strains were grown in human PBMC.avalues represent the concentration (µg/ml for soluble CD4 (sCD4) and human nmAbs IgG1b12, 2G12, 2F5, 4E10, or HIVIG) or the dilution (for serum samples) at which relative luciferase units (RLU) were reduced 50% compared to virus control wells. BB47, BB55, BB68, BB75, BB80, BB81, and BB87 are serum samples from individuals infected with HIV-1 clade C. HIVIG, polyclonal high-titer anti-HIV Ig preparation.bdata previously published [11] and given as basis of comparison.