Number of genes requiring additional simulations at each stage of adaptive permutation.

For each diagnosis and symptom factor, the number of loci requiring additional permutations after each stage of our adaptive procedure, given for both the Min P and truncated-product methods. For an observed test-statistic to be considered significant at a particular stage of permutation, there may be no greater than 10 simulated null statistics which are more extreme than the observed. For each gene-based test, the number of permutations performed at each stage is displayed parenthetically (100, 1,000, 10,000, and 100,000). Dim codes “del”, “dep”, “hal”, “manic”, “neg” are delusions, depressive symptoms, hallucinations, mania, and negative symptoms, respectively, and described elsewhere in full. †Min P finding for R3HDML. ‡truncated-product finding for C20orf39.