Transcriptome changes in overweight neutered female dogs undergoing a weight loss program with or without Spirulina (Arthrospira platensis) supplementation

In this study, in the context of a twelve-week randomized, double-blinded, controlled dietary trial, twelve healthy overweight neutered female dogs were equally divided into two groups receiving a weight loss diet with (SPI) or without (PLA) the supplementation of Arthrospira platensis (Spirulina). Blood samples were collected at three different time points, T0 (day 1), T1 (day 42), and T2 (day 84), and whole-blood transcriptomic effects were assessed using RNA-sequencing (RNA-seq).