SHED-derived exosomes ameliorate hyposalivation caused by Sjögren syndrome via Akt/GSK-3β/Slug-mediated ZO-1 expression.

SHED-exos can ameliorate Sjögren syndrome-induced hyposalivation through miRNAs mediated Akt/Slug/ZO-1 expression. SHED-exos were administered to the submandibular glands of nonobese diabetic mice, an animal model of Sjögren syndrome. The saliva flow rate was measured after pilocarpine intraperitoneal injection.Exosomal miRNAs were identified by microarray analysis.Akt/GSK-3β/Slug/ZO-1 expressions were examined by Western blot analysis.