Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP
收藏Protein Data Bank Japan2023-12-27 更新2026-03-21 收录
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Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Yuvaniyama, J, Chitnumsub, P, Kamchonwongpaisan, S, Vanichtanankul, J, Sirawaraporn, W, Taylor, P, Walkinshaw, M, Yuthavong, Y. Deposit date: 2003-02-03 Release date: 2003-05-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Insights into antifolate resistance from malarial DHFR-TS structures. NAT.STRUCT.BIOL., 10, 2003
创建时间：
2003-02-03
