AD-BXD [Ntg dataset 2]

Cg.5XFAD females (MMRRC Stock No #34848-JAX) were bred to males from BXD strains. The resulting F1 progeny were monitored throughout their lifepan to evaluate the effect of genetic background on cognitive and pathological traits. Samples here come from various Ntg-BXD lines at either 6 or 14 months of age. An earlier dataset of similar design (plus Non-transgenic littermates) was deposited as GSE101144. AD littermates of mice sampled here will be deposited as a separate GEO series. 71 Ntg samples. For final by-strain analysis, samples were averaged into strain/age/genotype/sex groups (For example, all D2 6mo 5XFAD males were averaged for final by-strain analysis)将Cg.5XFAD雌性小鼠（MMRRC库存编号#34848-JAX）与BXD品系雄性小鼠进行交配，对所得F1代后代开展全生命周期监测，以评估遗传背景对认知与病理表型的影响。本数据集的样本取自6月龄或14月龄的多株非转基因（non-transgenic, Ntg）-BXD品系小鼠。此前一项设计相似的数据集（包含非转基因同窝仔鼠）已以GSE101144号登录号存入基因表达综合数据库（Gene Expression Omnibus，GEO）。本研究中采样小鼠的阿尔茨海默病（Alzheimer's Disease, AD）模型同窝个体，将作为独立的GEO系列数据集提交。本次数据集共包含71份非转基因样本。在最终的品系水平分析中，所有样本将按品系、年龄、基因型、性别进行分组合并平均（例如，所有D2品系6月龄的5XFAD雄性小鼠样本将被合并平均，用于最终的品系水平分析）。