Klebsiella pneumoniae decolonization on Western-style diets

Competition between Klebsiella oxytoca and Klebsiella pneumoniae is investigated in mice fed one of three Western-style diets characterized by either high-starch, high-sucrose, or high-fat/high-sucrose content. Competition experiments in ampicillin-treated mice reveal that K. oxytoca promotes K. pneumoniae decolonization on all dietary backgrounds, however, mice on the high-fat/high-sucrose diet show reduced pathogen clearance. Microbiome analysis reveals that the combination of Western-style diets and ampicillin treatment synergize in microbiome impairment, particularly noticeable in the presence of high dietary fat content.