Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst
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https://figshare.com/articles/dataset/Catalyst-Controlled_Regioselective_Chlorination_of_Phenols_and_Anilines_through_a_Lewis_Basic_Selenoether_Catalyst/13079114
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资源简介：
We report a highly efficient ortho-selective
electrophilic chlorination
of phenols utilizing a Lewis basic selenoether catalyst. The selenoether
catalyst resulted in comparable selectivities to our previously reported
bis-thiourea ortho-selective catalyst, with a catalyst loading as
low as 1%. The new catalytic system also allowed us to extend this
chemistry to obtain excellent ortho-selectivities for unprotected
anilines. The selectivities of this reaction are up to >20:1 ortho/para,
while the innate selectivities for phenols and anilines are approximately
1:4 ortho/para. A series of preliminary studies revealed that the
substrates require a hydrogen-bonding moiety for selectivity.
创建时间：
2020-10-12
