Estimating and predicting the resolution of HiC libraries

High resolution HiC libraries are usually lightly sequenced before investing in a deep sequencing. We modeled HiC resolution in function of the sequencing depth to predict accurately the resolution of any high resolution HiC library given a small sequnecing batch of the library. To test our tool, we used public datasets as well as a newly generated dataset using Arima kit on mouse purified rods photoreceptors. Modeling HiC resolution using public datasets and HiC produced on mouse rods photoreceptors.