Extracellular processing of novel PDGFs

During the extracellular proteolytic activation of PDGF-C and PDGF-D chains, the CUB domains is removed and plasmin protease has been shown to proteolytically cleave within the hinge regions, and thus releasing the corresponding growth factor domains. In addition the protease tissue-type plasminogen activator (tPA) is also involved in the activation of PDGF-CC but not able to cleave and activate PDGF-DD.

在PDGF-C和PDGF-D链的细胞外蛋白酶激活过程中，CUB结构域被移除，并已有研究表明，纤溶蛋白酶在铰链区域进行蛋白水解切割，从而释放相应的生长因子结构域。此外，蛋白酶组织型纤溶酶原激活剂（tPA）亦参与PDGF-CC的激活，但无法切割并激活PDGF-DD。