Jiangya Kangxian Formula attenuates Cardiac Remodeling induced by Hypertension in Spontaneous Hypertensive Rat through modulating Mitochondrial Dysfunction

Kangxian formula (KXF), composed of 5 traditional Chinese distinct herbs including Panax Notoginseng, Radix Salviae, Spatholobus Suberectus Dunn, Hedysarum Multijugum Maxim and Citri Grandis Exocarpium, is a proved recipe showing promising outcomes in treating hypertension and cardiac remodeling in clinic. However, the effect of longterm treatment with KXF in such a condition and the related molecular mechanisms remain ambiguous. Here, we evaluated the effect of KXF on the gut microbiota and the prevention of hypertension and cardiac remodeling.抗纤方（Kangxian formula, KXF）由5味特色中药材组成，涵盖三七（Panax Notoginseng）、丹参（Radix Salviae）、鸡血藤（Spatholobus Suberectus Dunn）、多序岩黄芪（Hedysarum Multijugum Maxim）及化橘红（Citri Grandis Exocarpium）。该方剂为经临床验证的成熟验方，在高血压与心肌重构的临床治疗中已展现出良好的应用前景。然而，长期服用抗纤方对此类病症的干预效果及其相关分子机制仍尚不明确。本研究评估了抗纤方对肠道菌群的调控作用，及其对高血压与心肌重构的预防效果。