Additional file 1 of Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence

Additional file 1: Tables S1–S17. Table S1 Parameters for pathway enrichment analysis using the WEB-based GEne SeT AnaLysis Toolkit. Table S2 Genetic association estimates of circulating miRNAs used in the Mendelian randomization analyses. Table S3 Mendelian randomization analyses of circulating miRNAs and risk of colorectal cancer using cis IVs. Table S4 Mendelian randomization analyses of circulating miRNAs and risk of colorectal cancer using trans IVs. Table S5 Summary of the colocalization analysis results. Table S6 Sensitivity Mendelian randomization analyses of circulating miRNAs and risk of colorectal cancer using cis IVs. Table S7 MR-link-2 analyses of miRNAs on colorectal cancer risk. Table S8 Pleiotropy scan of the cis IVs. Table S9 Mendelian randomization analysis of genetic liability to risk of developing colorectal cancer and plasma miRNA concentrations. Table S10 Mendelian randomization analyses of circulating miRNAs and plasma proteins. Table S11 Mendelian randomization analyses of plasma proteins and colorectal cancer risk. Table S12 Suggestive miRNA and protein-target associations. Table S13 Mendelian randomization analyses plasma proteins on miRNAs. Table S14 Pathway enrichment analysis results. Table S15a miRNA expression profiles per tissue. Table S15b miRNA expression profiles per cancer tissue. Table S16 Correlation between miRNA and mRNA expression across tissues. Table S17 Correlation of miRNA expression across tissues and small compound sensitivity.