Frézier et al., 2026_Longitudinal somatosensory and spinal neuropeptidomic profiles in osteoarthritis chronic pain model in rats_Data raw

This dataset accompanies a longitudinal study of chronic osteoarthritis pain in the MI-RAT© surgical model. The study integrates quantitative sensory testing, joint structural assessments (macroscopic and histological scoring), and label-free spinal LC–MS/MS neuropeptidomic profiling over 84 days following OA induction. Behavioral measures include spontaneous pain, mechanical hypersensitivity, temporal summation, and endogenous inhibitory and facilitatory pain modulation. The dataset captures time-dependent changes in somatosensory processing, descending modulation, joint degeneration, and spinal neuropeptide remodeling.