Effects of beneficial mutations in new genotypes.

NIAID Data Ecosystem2026-03-07 收录

适应性突变

基因型功能评估

数据链接：

https://figshare.com/articles/dataset/_Effects_of_beneficial_mutations_in_new_genotypes_/257576 数据链接链接失效反馈

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资源简介：

Fitness values are given in units of doublings per hour plus or minus their standard errors.

创建时间：

2012-08-24

Deep mutational scanning of avian influenza PB2 to identify host-adaptive mutations

禽流感

适应性突变

This study aims to comprehensively map the effect of mutations to an avian influenza PB2 protein that enhance growth in different host cells. We mutagenized the PB2 gene from the influenza strain A/Gr

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HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes

免疫逃逸机制

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Certain Major Histocompatibility-I (MHC-I) types are associated with superior immune containment of HIV-1 infection by CD8+ cytotoxic T lymphocytes (CTLs), but the mechanisms mediating this containmen

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Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors.

肿瘤突变起源

适应性突变

The cells in most tumors are found to carry multiple mutations; however, based upon mutation rates determined by fluctuation tests, the frequency of such multiple mutations should be so low that tumor

PubMed Central1995-06-06 更新30

InToxSa phenogenomics platform: Staphylococcus aureus intracellular toxicity screening

毒性机制功能基因组学

适应性突变

Whole genome sequences of wildtype and mutants generated by allelic exchange to replicate patho-adaptive mutations associated with changes in intracellular toxicity.

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Fitness landscape of the vaccinia virus K3L H47R mutants in the context of the human PKR I378S mutant

适应性突变

宿主-病原体相互作用

Under selection pressure from the human PKR I378S variant, this study employed deep mutational scanning to systematically characterize the fitness effects of mutations in the vaccinia virus K3L protei

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Effects of beneficial mutations in new genotypes.

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