Chamber-Specific Chromatin Architecture Guides Functional Interpretation of Disease-Associated Cis-Regulatory Elements in Human Cardiomyocytes

Cis-regulatory elements (CREs) regulate cell-type-specific gene expression programs by interacting with target gene promoters. Here, we decode and functionally test CRE-promoter interactions in atrial and ventricular cardiomyocytes (CMs), linking them to heart disease and genetic risk variants. We analyzed the epigenome and chromatin interactions of human atrial, ventricular, and failing CMs.