GSDME-mediated Pyroptosis Promotes Atherosclerosis

NIAID Data Ecosystem2026-03-14 收录

动脉粥样硬化机制

细胞焦亡研究

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP357663 数据链接链接失效反馈

官方服务：

资源简介：

Human atherosclerosis single-cell transcriptome analysis revealed that GSDME is mainly expressed in macrophages. In vitro, ox-LDL induces the expression of GSDME and pyroptosis in macrophages.

创建时间：

2022-12-28

The influence of nt-LNA on cell composition and phenotypees in the atherosclerotic lesion.

动脉粥样硬化机制

单细胞RNA测序

Raw fastq files from paired-end, Illumina-based sequencing on NovaSeq6000 Apoe-/- mice were fed a western diet for 4 weeks and administered saline or nt-LNA (30 mg/kg) weekly. After 4 weeks, aortic a

NIAID Data Ecosystem80

KLF10 deficiency in CD4+ T cells promotes atherosclerosis progression by altering macrophage dynamics. KLF10 deficiency in CD4+ T cells promotes atherosclerosis progression by altering macrophage dynamics

动脉粥样硬化机制

免疫细胞互作网络

Gene expression profiling of aortic tissue from WT and CD4-KLF10-KO mice injected once with the AAV-PCSK9D377Y gain-of-function transgene and placed on high cholesterol diet. Overall design: 8 weeks o

NIAID Data Ecosystem60

Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells

动脉粥样硬化机制

泡沫细胞

Nicotinic acid (NA) regresses atherosclerosis in human imaging studies and reduces atherosclerosis in mice, mediated by myeloid cells, independent of lipoproteins. Since GPR109A is expressed by human

NIAID Data Ecosystem40

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. doi: 10.1038/nm.4109

动脉粥样硬化机制

平滑肌细胞转录组

The multiple claims about reactivation of the embryonic stem cell (ESC) pluripotency factor OCT4 in somatic cells are highly controversial due to the fact that there is no direct evidence that OCT4 ha

NIAID Data Ecosystem70

Gene expression profile on the single cell level of atherosclerotic plaque from mice with MCP1 knockout in Lgals3-transitioned smooth muscle cells. Gene expression profile on the single cell level of atherosclerotic plaque from mice with MCP1 knockout in Lgals3-transitioned smooth muscle cells

动脉粥样硬化机制

平滑肌细胞单细胞测序

Many different subsets of smooth muscle cells (SMC) are present in advanced atherosclerotic plaque. We used single cell sequencing to interrogate the impact of MCP1 made by Lgals+ smooth muscle cells

NIAID Data Ecosystem40

GSDME-mediated Pyroptosis Promotes Atherosclerosis

资源简介：

相关数据集