Skin Microbiome of Monogenic Skin Disorder

Ichthyosis introduces multiple sources of disturbance to the skin, including the direct biochemical consequences of the genotype, the phenotypic changes in skin physiology, and an altered skin microbiome. The association between changes in the skin microbiome and the disease's genotypic and phenotypic effects are historically obscured. Here we characterize the skin microbiome of healthy participants and ichthyosis patients, before assessing the association between these microbiome features and the ichthyosis genotype and phenotype while adjusting for contextual host covariables. ]]> Inclusion Criteria:All participants, with the exception of one, were at least 18 years of agehad used no oral or topical antibiotic in the month prior to samplingused only Dove soap for bathing for one week prior to samplingapplied no emollients for 24 hours prior to sampling.Ichthyosis subjects had genetic sequence-confirmed causative mutations in either KRT1, KRT2, KRT10, TGM1, ABCA12, ALOX12B, NIPAL4, PNPLA1, or SPINK5.]]>