CRYSTAL STRUCTURE OF WILD-TYPE PLK1 KINASE DOMAIN IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1 AND A SELECTIVE DARPIN

CRYSTAL STRUCTURE OF WILD-TYPE PLK1 KINASE DOMAIN IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1 AND A SELECTIVE DARPIN Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, DESIGNED ANKYRIN REPEAT PROTEIN 3H10, GLYCEROL, ... Authors: Hillig, R.C, Matias, P.M, Bandeiras, T.M, Schulze, V.K, Siemeister, G, Schmitz, A.A, Eberspaecher, U, Bomer, U. Deposit date: 2025-05-16 Release date: 2025-11-26 Last modified: 2025-12-10 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Polo-like kinase 1-inhibitor co-complex structures via the surface-entropy reduction approach and a DARPin-assisted approach. Acta Crystallogr D Struct Biol, 81, 2025