Complex Peptidyl Nucleoside Antibiotics: Efficient Syntheses of the Glycosyl Nucleoside Amino Acid Cores

Employing an amino acid chiral template strategy, the present research describes a general and
highly efficient protocol for the rapid construction of enantiopure furanosyl and pyranosyl nucleoside
amino acid cores as present in various complex peptidyl nucleoside antibiotics. Starting from easily
available d-serine, the strategy and the approach involve rapid and efficient stereoselective synthesis of five- or six-membered lactone amino alcohols, followed by incorporation of the required
functionalities of the target molecules on these strategically functionalized chiral templates.