Results of multivariable MR with lipid trait summary statistics from distinct cohorts.

Risk for all BCs was used as the outcome. Within a test, the effect estimates for each lipid trait are from different data sets (MVP or GLGC). Each test is separated by an empty row. Exposure_Dataset: lipid trait (or BMI) used as exposure and the data set for lipid summary statistics; N_SNPs: number of genetic instruments used in MR test; CI_95_L: lower bound of 95% CI; CI_95_U: upper bound of 95% CI; P: P-value of MR test; Before/after pruning: results from MR before or after pruning for instrument heterogeneity. BC, breast cancer; BMI, body mass index; CI, confidence interval; GLGC, Global Lipids Genetics Consortium; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MR, Mendelian randomization; MVP, Million Veteran Program; OR, odds ratio; TG, triglyceride. (XLSX)