System immunology-based identification of blood transcriptional modules correlating to antibody responses in sheep. Transcripts of ovine peripheral blood mononuclear cells following vaccination

Inactivated vaccines lack immunogenicity and therefore require potent adjuvants. To adapt a rational approach to this aim, understanding the in vivo effects of adjuvants is essential. Here we compared non-adjuvanted and liposome-formulated foot-and-mouth disease virus antigen together with TLR4 and TLR7 ligands as immunostimulants. We used a system immunology-based analysis of ovine blood transcriptional modules (BTM) to dissect innate immune responses relating antibody or to haptoglobin.