Serumal Lipidomics Reveals the Anti-inflammatory Effect of Flax Lignans and Sinapic Acid in High-Fat-Diet-Fed Mice

Flax
lignans (SDG) and sinapic acid (SA) both have the function
of antioxidation and anti-inflammation. However, previous studies
have focused mainly on biochemical measurements, gene expression analysis,
and clinical assessments. There are limited studies that systematically
reveal the underlying mechanism of the anti-inflammation effect of
SDG or SA from the lipidomic point of view. Herein, the integrated
lipidomic profiling platform was used for the analysis of free fatty
acids (FFAs), phospholipids (PLs), triacylglycerols (TAGs), and oxylipins
in high-fat (HF)-diet-fed mice after SDG or SA administration. Dietary
supplementation of SDG or SA downregulated the levels of total TAGs
and FFAs in the ApoE–/– mice model. Furthermore,
28 potential lipids were screened out and considered as key evaluation
factors to understand the anti-inflammation function and mechanism
of SDG and SA. The results indicated that the anti-inflammatory effect
of SDG and SA was principally exerted via regulation of lipid homeostasis.