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New Approach to the Synthesis of Macrocyclic Tetralactones via Ring-Closing Metathesis Using Grubbs' First-Generation Catalyst

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/New_Approach_to_the_Synthesis_of_Macrocyclic_Tetralactones_via_Ring_Closing_Metathesis_Using_Grubbs_First_Generation_Catalyst/3025951
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A facile and efficient route to synthesize macrocyclic tetralactones with different ring sizes having a wide variety of spacers is described. The application of ring-closing metathesis for the synthesis of macrocyclic tetralactones is demonstrated with many examples in excellent yield. The representative structure of macrocyclic tetralactones is characterized by X-ray crystallography.
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2007-02-16
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