Inhibition of the dorsomedial striatal direct pathway is essential for the execution of action sequences

Contrary to the previous notion that the dorsomedial striatum (DMS) is crucial for acquiring new learning, accumulated evidence has suggested that the DMS also plays a role in the execution of already learned action sequences. Here, we examined how the direct and indirect pathways in the DMS regulate action sequences using a task that requires animals to press a lever consecutively. Cell-type-specific bulk Ca2+ recording revealed that the direct pathway was inhibited at the time of sequence execution. The sequence-related response was blunted in trials where the sequential behaviors were disrupted. Optogenetic activation at the sequence start caused distraction of action sequences without affecting motor function or memory of the task structure. By contrast with the direct pathway, the indirect pathway was slightly activated at the start of the sequence, but the optogenetic suppression of such sequence-related signaling did not impact the behaviors. These results suggest that the inhibi..., , , # Data from: Inhibition of the dorsomedial striatal direct pathway is essential for the execution of action sequences

## Description of the Data and file structure

The .bin files named as A0234, A0241, A0246, A0249, A0252, A0284 and A0297 indicate photometry data of D1-YC mice.

The .bin files named as A0182, A0201, A0202, A0253, and A0288 indicate photometry data of D2-YC mice.

The .bin files named as A0238, A0240, A0278, A0279, A0280, A0281 indicate optogenetic data of D1-ChR2 mice.

The .bin files named as A0264, A0275, A0276, A0292 and A0293 indicate optogenetic data of D2-ArchT mice.
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